Technology blogs
- DeepMind
- OpenAI (OpenAI Cookbook)
- Google AI (on Twitter), Google The Keyword
- Microsoft Research
- Meta
- NVIDIA
- IBM Research
- Amazon Science
- Baidu Research
- Stability.AI
- Hugging Face
- Baker Lab
- Metaphysic
- Runway Research (on Twitter)
- KDnuggets
- Width.ai
- PapersWithCode
Technology interviews
- Lex Fridman
(e.g. with Demis Hassabis, Yann LeCun, Yoshua Bengio, Geoffrey Hinton, Jürgen Schmidhuber, Andrew Ng, Mark Zuckerberg, Andrej Karpathy, Ilya Sutskever, David Silver, Elon Musk, Vitalik Buterin, Donald Knuth, Guido van Rossum, Bjarne Stoustrup, Leonard Susskind, Frank Wilczek, Lee Smolin, Sean Carroll, Scott Aaronson, Brian Greene, Ray Kurzweil, Max Tegmark, Nick Bostrom, Michio Kaku, Ray Dalio, Daniel Kahneman, David Sinclair, Stephen Wolfram, Magnus Carlsen, Garry Kasparow, …) - The Logan Bartlett Show
- Machine Learning Street Talk
- Heros of deep learning, Heros of NLP
Learning
- Yannic Kilcher
- AI Coffee Break
- TechWorld with Nana
- LifeArchitect.ai (Alan Thompson)
- DeepLearningAI (Andrew Ng)
- Dive into Deep Learning
- Stanford Online
- Stanford: Natural Language Understanding
- Tübingen Machine Learning
- StatQuest with Josh Starmer
- Backprop
- Kaggle
- LeetCode / CodeForces
- StartupClass (Sam Altman)
- Rasa Learning Center
- Matt Wolfe
Finance
Longevity
(see Ray Kurzweil, David Sinclair, Brad Stanfield)
-
Slow down aging
(main strategy: avoid cardiovascular disease and cancer, avoid inflammation)
- Proper life style (mediterranean diet, avoid sugar, no overweight, no smoking, sufficient sleep, manage stress [meditation], socializing, avoid alcohol, avoid direct sun)
- Moderate stress on your body ([intermittent] fasting, exercising, sauna, cold temperatures)
- Tests (blood test[especially LDL, homocysteine], blood pressure, ultrasound or more advanced imaging methods, sleep apnea, coronary artery calcium (CAC), skin, PSA (for men), breast (for women), Galleri, gene test, epigenetic test)
-
Supplements
-
David Sinclair (2022):
- NMN (nicotinamide mononucleotide), 1g
- TMG (trimethylglycine = betaine), 500mg,
(methyl donator for NMN) - Resveratrol, 1g (together with yoghurt or olive oil)
- Metformin, 1g (needs prescription, alternatively: berberine)
- Aspirin (ASA = acetylsalicylic acid), 83mg
- Vitamins D3 (4000-5000 IU) , K2 (180-360mcg)
-
Ray Kurzweil (2009):
- (under development …)
-
Brad Stansfield (2022):
- Collagen, 10 g
- Psyllium Husk, 4g
- Niacin (vitamin B3), 100mg, (boost NAD+)
- TMG (trimethylglycine = betaine), 1g
- Vitamin K2 MK-7, 120mcg
- Vitamin D3, 1000 IU
- Omega-3 (DHA/EPA), (445mg DHA, 665mg EPA)
- Hyaluronic acid, 200mg
- Zinc, 8.4mg
- Creatine, 2.5g
- Melatonin, 300mcg
- Magnesium Taurate, 125mg
-
Watch list:
Urolithin A,
Glucosamine,
AKG,
SIRT 6 activator,
SGLT2 inhibitors,
Finasteride,
Rapamycin
-
DoNotAge (2022)
- SIRT6 activator (Fucus Vesiculosus)
- NMN, 1g
- TMG, 1g
- CA-AKG, 800mg
- Sulforaphane, 200mg
- Hydrolysed Collagen Peptides, 300g
- Quercetin, 800mg
- Spermidine, 8mg
- Apigenin, 500mg
- Hyaluronic acid, 200mg
- Resveratrol, 1g
- Vitamin D3, K2, Magnesium (5000 IU D3, 120mcg K2 [Mk-7], 250mg Magnesium [L-Threonate])
- NR (alternative to NMN), 700mg
- Fisetin, 800mg
- Berberine, 1g
- SureSleep (Prunus Cerasus, Rhodiola Rosea, Valerian Root), 400mg, (no melatonin!)
-
Others
- Curcumin (active ingredient of turmeric) together with piperine (active component of black pepper for increased bioavailability), 1g
- Glucosamine (15% lifespan extension)
- Rapamycin (needs prescription, 26% lifespan extension)
- NAC & Glutathione (24% lifespan extension)
- Glycine
- 7-Alpha Estradiol (19% lifespan extension)
- Ashwagandha
- Spermidine (10% lifespan extension)
- Sulforaphane, 200mg (activate NRF2 => create CoQ10)
- Apigenin, 250mg (inhibits CD38 [CD38 reduces NAD+] )
-
David Sinclair (2022):
-
Reverse aging (until now just tested in mice)
-
Epigenetic reprogramming based on Yamanaka factors
(➩ startups: Altos Labs, NewLimit)- Yamanaka factors = 4 genes: Oct4, Sox2, Klf4, c-Myc
- Proteins coded by these genes induce adult cells to become pluripotent stem cells (iPSCs), i.e. cells that can develop into any specific cell type (Nobel price in medicine 2012 by Shinya Yamanaka).
- An adult cell is a specialized cell in which certain genes have been turned on or off. This is achieved by adding methyl groups (CH3) to the DNA and/or acetyl groups (COCH3) to the histones around which the DNA is wrapped and depends on the environment of the cell. This same process of DNA methylation that is responsible for cell specialization seems to be also a main contributor to aging.
- In a way that is not yet completely understood Yamanaka factors restore the methylation pattern of younger cells (which is responsible for which genes are transcribed into proteins).
- Epigenetic clocks (like the Horvath clock) determine the methylation pattern of a few hundred CpG sites (DNA regions where cytosine is followed by guanine in 5′->3′ direction) and can precisely predict all cause mortality in later life (with a median error of 3.6 years for the Horvath clock). More precise epigenetic clocks than the Horvath clock already exist (with median error of 2.15 years).
- Avoiding the c-Myc gene avoids generating cancer in the de-methylation process. The OSK (Oct4, Sox2, Klf4) genes seem to be safe.
- Putting OSK genes into an adeno-associated virus (AAV) under the control of a tetracycline response element (TRE) and injecting the virus into mice allows to activate the OSK genes on demand by giving tetracycline. In this way the reversal of aging can be precisely controlled.
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Epigenetic reprogramming based on Yamanaka factors