• Technology blogs
  • Technology interviews & overviews
    • Lex Fridman (e.g. with Demis Hassabis, Yann LeCun, Yoshua Bengio, Geoffrey Hinton, Juergen Schmidhuber, Andrew Ng, Mark Zuckerberg, Ilya Sutskever, David Silver, Elon Musk, Vitalik Buterin, Donald Knuth, Guido van Rossum, Bjarne Stoustrup, Leonard Susskind, Frank Wilczek, Lee Smolin, Sean Carroll, Scott Aaronson, Brian Greene, Ray Kurzweil, Max Tegmark, Nick Bostrom, Michio Kaku, Ray Dalio, Daniel Kahneman, David Sinclair, Stephen Wolfram, Magnus Carlsen, Garry Kasparow, …)
    • Machine Learning Street Talk
    • Yannic Kilcher
    • AI Coffee Break
  • Longevity
    (see Ray Kurzweil, David Sinclair, Brad Stanfield)
    • Slow down aging
      (main strategy: avoid cardiovascular disease and cancer)
      • Proper life style (mediterranean diet, avoid sugar, no overweight, no smoking, sufficient sleep, manage stress, socializing, avoid alcohol, avoid direct sun)
      • Moderate stress on your body ([intermittent] fasting, exercising, sauna, cold temperatures)
      • Test (blood, ultrasound or more advanced imaging methods, skin, PSA (for men), breast (for women), Galleri, gene test, epigenetic test)
      • Supplements
        • David Sinclair (2022):
          • NMN (nicotinamide mononucleotide), 1 g
          • TMG (trimethylglycine = betaine), 500 mg
          • Resveratrol, 1 g (together with yoghurt or olive oil)
          • Metformin, 1 g (needs prescription, alternatively berberine)
          • Aspirin (ASA = acetylsalicylic acid), 83mg
          • Vitamins D3 (4000-5000 IU) , K2 (180-360 micrograms)
        • Ray Kurzweil (2009):
          • CA-AKG (Calcium alpha-ketoglutarate)
          • Omega-3 lipids (EPA [eicosa-pentaeonic acid],
            DHA [decosa-hexaeonic acid])
          • Alpha-lipoic acid (ALA)
          • Coenzyme Q10 (coQ10)
          • Spermidine
          • Quercetin, 500 mg
          • Fisetin, 500 mg
        • Others:
          • Curcumin (active ingredient of turmeric) together with piperine (active component of black pepper for increased bioavailability), 1g
          • Glucosamine (15% lifespan extension)
          • Sulforaphane
          • SIRT6 activator (Fucus Vesiculosus)
          • Rapamycin (needs prescription)
    • Reverse aging (until now just tested in animals)
      • Epigenetic reprogramming based on Yamanaka factors
        • Yamanaka factors = 4 genes: Oct4, Sox2, Klf4, c-Myc
          (Nobel price in medicine 2012)
        • Proteins coded by these genes induce adult cells to become pluripotent stem cells (iPSCs), i.e. cells that can develop into any specific cell type.
        • An adult cell is a specialized cell in which certain genes have been turned on. This is achieved by adding acetyl groups (COCH3) to the histones around which the DNA is wrapped and depends on the environment of the cell. This allows that the gene can be read and the encoded protein is generated. These generated proteins are responsible for the special attributes of a certain tissue although all cells in the body are based on the same DNA. This same process that is responsible for cell specialization is also responsible for aging.
        • Yamanaka factors remove acetyl groups from the histones and silence in this way certain genes that have been switched on during the aging process.
        • Avoiding the c-Myc gene avoids generating cancer in this process. The OSK (Oct4, Sox2, Klf4) genes seem to be safe.